CHAPTER 1 Neurotransmitter networks Elaine Perry and Allan Young i. Introduction This first chapter sets the scene for subsequent exploration of potential ...

This pioneering book explores in depth the role of neurotransmitters in conscious awareness. The central aim is to identify common neural denominators of conscious awareness, informed by the neurochemistry of natural, drug induced and pathological states of consciousness. Chemicals such as acetylcholine and dopamine, which bridge the synaptic gap between neurones, are the 'neurotransmitters in mind' that form the substance of the volume, which is essential reading for all who believe that unravelling mechanisms of consciousness must include these vital systems (...) of the brain.Up-to-date information is provided on: Psychological domains of attention, motivation, memory, sleep and dreaming that define normal states of consciousness. Effects of chemicals that alter or abolish consciousness, including hallucinogens and anaesthetics. Disorders of the brain such as dementia, schizophrenia and depression considered from the novel perspective of the way these affect consciousness, and how this might relate to disturbances in neurotransmission.(Series B). (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

When recalling autobiographical memories, individuals often experience visual images associated with the event. These images can be constructed from two different perspectives: first person, in which the event is visualized from the viewpoint experienced at encoding, or third person, in which the event is visualized from an external vantage point. Using a novel technique to measure visual perspective, we examined where the external vantage point is situated in third-person images. Individuals in two studies were asked to recall either 10 or (...) 15 events from their lives and describe the perspectives they experienced. Wide variation in spatial locations was observed within third-person perspectives, with the location of these perspectives relating to the event being recalled. Results suggest remembering from an external viewpoint may be more common than previous studies have demonstrated. (shrink)

Regular polysemes are sets of ambiguous words that all share the same relationship between their meanings, such as CHICKEN and LOBSTER both referring to an animal or its meat. To probe how a distributional semantic model, here exemplified by bidirectional encoder representations from transformers (BERT), represents regular polysemy, we analyzed whether its embeddings support answering sense analogy questions similar to “is the mapping between CHICKEN (as an animal) and CHICKEN (as a meat) similar to that which maps between LOBSTER (as (...) an animal) to LOBSTER (as a meat)?” We did so using the LRcos model, which combines a logistic regression classifier of different categories (e.g., animal vs. meat) with a measure of cosine similarity. We found that (a) the model was sensitive to the shared structure within a given regular relationship; (b) the shared structure varies across different regular relationships (e.g., animal/meat vs. location/organization), potentially reflective of a “regularity continuum;” (c) some high-order latent structure is shared across different regular relationships, suggestive of a similar latent structure across different types of relationships; and (d) there is a lack of evidence for the aforementioned effects being explained by meaning overlap. Lastly, we found that both components of the LRcos model made important contributions to accurate responding and that a variation of this method could yield an accuracy boost of 10% in answering sense analogy questions. These findings enrich previous theoretical work on regular polysemy with a computationally explicit theory and methods, and provide evidence for an important organizational principle for the mental lexicon and the broader conceptual knowledge system. (shrink)

Over the past decade, feminist philosophers have gone a long way toward identifying and explaining the phenomenon that has come to be known as epistemic injustice. Epistemic injustice is injustice occurring within the domain of knowledge (e.g., knowledge production and transmission), which typically impacts structurally marginalized social groups. In this paper, we argue that, as they currently work, algorithms on social media exacerbate the problem of epistemic injustice and related problems of social distrust. In other words, we argue that algorithms (...) on social media recreate and reify the conditions that lead to some groups being systematically denied the full status of knowers, thereby corrupting the epistemic terrain and, with it, systems of social trust and cooperation. We argue that algorithms do this in two ways—namely, via what we are calling algorithmic targeting and algorithmic sorting. (shrink)

If, as the new tenseless theory of time maintains, there are no tensed facts, then why do our emotional lives seem to suggest that there are? This question originates with Prior’s ‘Thank Goodness That’s Over’ problem, and still presents a significant challenge to the new B-theory of time. We argue that this challenge has more dimensions to it than has been appreciated by those involved in the debate so far. We present an analysis of the challenge, showing the different questions (...) that a B-theorist must answer in order to meet it. The debate has focused on the question of what is the object of my relief when an unpleasant experience is past. We outline the prevailing response to this question. The additional, and neglected, questions are, firstly—‘Why does the same event elicit different emotional responses from us depending on whether it is in the past, present, or future?’ And secondly—‘Why do we care more about proximate future pain than about distant future pain?’ We give B-theory answers to these questions, which appeal to evolutionary considerations. (shrink)

_ Source: _Page Count 29 This essay offers a working analysis of the trait of intellectual perseverance. It argues that intellectual perseverance is a disposition to overcome obstacles, so as to continue to perform intellectual actions, in pursuit of one’s intellectual goals. The trait of intellectual perseverance is not always an intellectual virtue. This essay provides a pluralist analysis of what makes it an intellectual virtue, when it is one. Along the way, it argues that the virtue of intellectual perseverance (...) can be contrasted with both a vice of deficiency and a vice of excess. It also suggests that the virtues of intellectual courage and intellectual self-control are types of intellectual perseverance. The essay ends with several open questions about the virtue of intellectual perseverance. My hope is that this essay will stimulate further interest in, and analysis of, this important intellectual trait. (shrink)

ABSTRACTThe private provision of security services has attracted a great deal of recent attention, both professional and popular. Much of that attention suggests the questioned moral legitimacy of the private vs. public provision of security. Linking the literature on moral legitimacy and responsibility from new institutional and stakeholder theories, we examine the relationship between moral legitimacy and responsible behavior by both private security companies and their stakeholders. We ask what the moral-legitimacy-enhancing responsibilities of both might be, and contribute to both (...) literatures and their managerial implications by detailing the content of those responsibilities, emphasizing the reciprocal nature of moral obligations. We suggest that the moral legitimacy of the industry depends upon responsible behavior by both PSCsandtheir stakeholders. (shrink)

This essay offers a working analysis of the trait of intellectual perseverance. It argues that intellectual perseverance is a disposition to overcome obstacles, so as to continue to perform intellectual actions, in pursuit of one’s intellectual goals. The trait of intellectual perseverance is not always an intellectual virtue. This essay provides a pluralist analysis of what makes it an intellectual virtue, when it is one. Along the way, it argues that the virtue of intellectual perseverance can be contrasted with both (...) a vice of deficiency and a vice of excess. It also suggests that the virtues of intellectual courage and intellectual self-control are types of intellectual perseverance. The essay ends with several open questions about the virtue of intellectual perseverance. My hope is that this essay will stimulate further interest in, and analysis of, this important intellectual trait. (shrink)

How can we cultivate intellectual virtues in our students? I provide an overview of virtue epistemology, explaining two types of intellectual virtues: reliabilist virtues and responsibilist virtues. I suggest that both types are acquired via some combination of practice on the part of the student and explanation on the part of the instructor. I describe strategies for teaching these two types of virtues in the classroom, including an activity for teaching the skill of using the square of opposition, and several (...) activities that encourage students to practice open-minded acts, intellectually courageous acts, and the motivation for truth. (shrink)

A common argument for the social value of sport is that athletes serve as heroes who inspire people – especially young people – to strive for excellence. This argument has been questioned by sport philosophers at a variety of levels. Not only do athletes seem unsuited to be heroes or role models in the conventional sense, it is unclear more generally what the social and educational value of athletic excellence could be. In this essay, I construct an argument for the (...) social and educational value of sport built upon the relationship between athletes, heroes, and the song culture that celebrated them in ancient Greece. On this model, athletes are neither heroes nor role models in the conventional sense. Rather, athletes, athletics, and the poets who extolled them were part of a cultural conspiracy to celebrate and inspire virtue by connecting a community with its heroic past. Festivals such as the Olympic Games, but also local events such as funeral games, educated and unified communities by cultivating an aesthetic appreciation for virtue and by inspiring youth to strive for it. Ancient athletes were not heroes, rather they re-enacted heroic struggles, thereby experiencing heroic virtues, and inspiring both artists and spectators to bond with the higher ideals implied by their shared belief in divine ancestry. In this way, athletes, athletics, and the media that celebrated them played important social and educational roles. Insofar as modern sport performs a similar service, its association with heroism and with moral education may ultimately be justified. (shrink)

The recent literature on ad hominem argument contends that the speaker’s character is sometimes relevant to evaluating what she says. This effort to redeem ad hominems requires an analysis of character that explains why and how character is relevant. I argue that virtue epistemology supplies this analysis. Three sorts of ad hominems that attack the speaker’s intellectual character are legitimate. They attack a speaker’s: (1) possession of reliabilist vices; or (2) possession of responsibilist vices; or (3) failure to perform intellectually (...) virtuous acts. Legitimate ad hominems conclude that we should not believe what a speaker says solely on her say-so. (shrink)

In the tense religious climate of the late Renaissance (ca. 1550-1650), traditional charges of impiety directed against Aristotle carried new weight. Many turned to alternative philosophical authorities in the search for a truly pious philosophy. Another, "most pious" solution was to ground natural philosophy on a literal reading of the Bible, especially Genesis. I examine this kind of physics, often called Mosaic, or sacred, or Christian, through the example of Johann Amos Comenius and those whom he praises as predecessors in (...) his attempt to reform physics according to the "divine light" of Scripture. In analyzing the works of these authors, I conclude that what they shared most effectively was an agenda rather than a practice. They defended the single, universal truth of a "Christian philosophy" grounded in biblical literalism against the impious excesses of philosophical naturalism, on the one hand, and against the antiphilosophical attacks of extreme theologians, on the other hand. This peculiar strand of natural philosophy, neither traditional nor "modern," needs to be included in attempts to map the complex dynamics of contemporary debates and self-presentations. -/- . (shrink)

This article argues that an interlocutor’s deference and open-mindedness can indicate servility rather than virtuous humility. Section 1 evaluates an influential philosophical analysis of the virtue of humility and two psychological measures, all of which emphasize the contrast between humility and arrogance. Section 2 develops a philosophical analysis of servility, building on the limitations-owning view. It argues that servility is an unwillingness or inability to be attentive to and own one’s strengths, and a disposition to be overly attentive to and (...) over-own one’s limitations. Section 3 sketches a picture of servility in political discourse, suggesting that we can expect servility to be positively correlated with deferring to others, open-mindedness, and belief-revision, and negatively correlated with anger. Section 4 sketches a picture of countering servility in political discourse through the virtues of pride and humility. By comparison with servility, we can expect virtuously proud and virtuously humble people to exhibit higher correlations with refusals to defer, to be open, to engage, and to revise beliefs. It points us toward psychological measures that aim to distinguish the virtue of humility from the vice of servility. (shrink)

While 90 percent of participants in a 2005 Gallup poll indicated that they would donate an organ if asked, only 40 percent of Americans have registered to do so, according to 2012 data from Donate Life America; likely even fewer have shared their donation wishes with loved ones. Undoubtedly, the single biggest reason for the discrepancy between the number of potential transplants and the number actually performed is our failure to talk with loved ones about our wishes regarding organ donation. (...) Although many resources already exist to hold these conversations, we can do more, and the emergence of social media provides an intriguing new opportunity. Two years ago, Organize.org set out to create the first nationwide organ donation registry in the United States. (shrink)

This article argues that the Seven Solutions in the US, and the Research Excellence Framework in the UK, manifest the vice of epistemic insensibility. Section I provides an overview of Aristotle's analysis of moral vice in people. Section II applies Aristotle's analysis to epistemic vice, developing an account of epistemic insensibility. In so doing, it contributes a new epistemic vice to the field of virtue epistemology. Section III argues that the (US) Seven Breakthrough Solutions and, to a lesser extent, the (...) (UK) Research Excellence Framework manifest two key features of the vice of epistemic insensibility. First, they promote a failure to desire, consume, and enjoy some knowledge that it is appropriate to desire, consume, and enjoy. Second, they do so because they wrongly assume that such knowledge is not epistemically good. The Solutions wrongly assume that any research that lacks ‘impact’, in the form of funding, thereby lacks epistemic value. The REF wrongly assumes of otherwise comparable bodies of research, that the research that lacks ‘impact’ has less epistemic value. (shrink)

“Tense” is an ambiguous term. It refers to a grammatical feature of natural languages, and also to a disputed metaphysical feature of temporal reality. The chapter examines both the linguistic and the metaphysical issue, and considers the relation between them. Then, it presents and evaluates some linguistic, metaphysical and evolutionary arguments that the inference from language to metaphysics is not justified. The metaphysical debate is concerned with whether or not tense exists in reality. The linguistic issues are interesting, and worthy (...) of study in their own right, but care should be taken not to run them together with the metaphysical issues. Finally, the chapter explores the importance of tensed belief and notion of ‘taking tense seriously’, which has been much discussed in the philosophical literature, and the importance of tensed beliefs to agency and successful timely action. (shrink)

McTaggart famously argued that time is unreal. Today, almost no one agrees with his conclusion.1 But his argument remains thelocus classicusfor both the A–theory and the B-theory of time. I want to show how McTaggart's argument provided the impetus for both of these opposing views of the nature of time. I will also present and defend what I take to be the correct view of the nature of time.

(2013). What Shall We Do with Analytic Metaphysics? A Response to McLeod and Parsons. Australasian Journal of Philosophy: Vol. 91, No. 1, pp. 179-182. doi: 10.1080/00048402.2012.762029.

Digital data is an increasing and continual presence across the sites, activities and relationships of everyday life. In this article we explore what data presence means for the ways that the everyday is organised, sensed, and anticipated. While digital data studies have demonstrated how data is deeply entangled with the way in which everyday life is lived out and valued, at the same time our relationships with data are riddled with anxieties or small niggles or tricky trade-offs and their use (...) is often chaotic and muddled, part of the inevitable uncertainty about what will happen next. If the presence of data is part of the environments we inhabit, this raises the question of how and why data is valuable to us and what forms of hope and trust enable this value to further develop. (shrink)

By Maurice A. Finocchiaro Studies in Logic, Logic and Argumentation, Vol. 42. London: College Publications, 2013. Pp. vii, 1-279. ISBN 978-1-84890-097-4. UK£12 US$17.10 CDN$21.12.

This chapter contains sections titled: The Structure of Virtue Ethics and Virtue Epistemology Virtue and Context Virtue and Emotion Virtues and Vices Acknowledgments References.

Arts of Living on a Damaged Planet: Ghosts and Monsters of the Anthropocene. Edited By Tsing Anna Lowenhaupt, Swanson Heather Anne, Gan Elaine, Bubandt Nils.

The paper aims to provide an analysis and critique of Carl Wellman’s account of conduction presented in Challenge and Response and Morals and Ethics. It considers several issues, including: reason-ing vs. argument, the definition vs. the three patterns of conduction, pro and con arguments as dialogues, their assessment, the concept of validity, applications beyond moral arguments, argument type vs. as crite-rion of evaluation.

Ten years ago, when I was president and chief executive officer of Rady Children's Hospital in San Diego, if you had asked me about our commitment to environmental sustainability or about the hospital's carbon footprint, I would have given you a blank look. The issues were simply not on my radar screen. And that was true of most health care leaders.The good news? Environmental sustainability is becoming a health care priority, and exciting progress is occurring. In Greening Health Care: How (...) Hospitals Can Heal the Planet, Kathy Gerwig eloquently relates how one leading large health care system, Kaiser Permanente, achieved remarkable results in responding to the environmental health challenge over the past several years. (shrink)

Are there any logical norms for argument evaluation besides soundness and inductive strength? The paper will look at several concepts or models introduced over the years, including those of Wisdom, Toulmin, Wellman, Rescher, defeasible reasoning proponents and Walton to consider whether there is common ground among them that supplies an alternative to deductive validity and inductive strength.

This chapter contains sections titled: Aristotle on Moral Temperance, Self‐Indulgence, and Insensibility Epistemic Temperance, Self‐Indulgence, and Insensibility Acknowledgments References.

The role of divine power in Aquinas’s spiritual doctrine has often been neglected in favor of a focus on the primacy of charity, the controlling virtue of spiritual progress. The tendency among some thinkers (e.g. Polkinghorne) to juxtapose divine love and power stems from the stress on divine immanence at the cost of divine transcendence, and from an evolutionary (vs. classical) view of God with its ‘kenotic’ theodicy. A study of the ways in which divine power grounds and directs the (...) spiritual life highlights the robust role that metaphysics plays in spiritual ascent for Aquinas, and offers a philosophical entry point to his doctrine. Themes in his doctrine of the spiritual life incorporate Platonic transcendent causal plenitude and Aristotelian causal axioms and motifs of growth and unity. From the side of theology, divine power is analyzed through several lenses, including power through weakness in Christ, the sin of Lucifer against the gift of being in contrast to the counsel of obedience, and the role of Christ’s human nature in the Church. Taken together, these themes combine to characterize divine power as redemptive medicine, as opposed to a distant, arbitrary force, and to reveal the ways in which Aquinas applies metaphysical insights to the supernatural order. (shrink)

Philosophical forces gathered in late nineteenth and early twentieth century Catholic Modernism have crystallized into theological views which permeate the antinomian atmosphere in the Church today, resulting in an ongoing Catholic identity problem, both within the Church and in relation to the world. In place of the perennial philosophy and its contemplative ideal, many now welcome the incoherence of broad philosophical and theological pluralism, while pastoral practice is infused with the fruits of pragmatism and the rhetoric of false dichotomies (justice/mercy, (...) intellectual/pastoral, tradition/living faith, speculative truth/charity, for example). To reverse this anti-intellectual course, rehabilitation of Aquinas’s positions on the primacy of the speculative order and contemplative charism, his integration of natural, revealed and mystical wisdoms, and his sense of objective worship, is needed. A brief account of the robust role of philosophy in the Church’s mission and of Gilson’s nuanced position on the encounter of Thomism and Modernism supports this assertion. (shrink)

Quassim Cassam (Cassam, Extremism, Routledge, 2022a) and Paul Katsafanas (Katsafanas, Philosopher’s Imprint 19:1–20, 2019) have argued that fanaticism and extremism are morally and epistemically vicious. I suggest an alternative approach that: (i) explains what makes fanaticism and extremism vicious in the very many cases in which they are; but also (ii) allows for cases in which fanaticism and extremism aren’t vices and may even be liberatory-virtues. My hope is that this approach might serve as a resource for those in liberatory (...) struggles. (shrink)

The title of John Heil’s book From an Ontological Point of View is, of course, an adaptation of the title of Quine’s influential collection of essays From a Logical Point of View, published fifty years earlier in 1953. Quine’s book marked the beginning of a sea change in philosophy, away from ordinary language, armchair philosophising involving introspective examination of concepts, towards a more rigorous, analytical and scientific approach to answering philosophical questions. Heil’s book will, I think, mark the beginning of (...) another sea change in philosophy, this time, away from a focus on language, and towards a focus on ontology. For that reason, the replacement of ‘Logical’ with ‘Ontological’ in Heil’s title is apposite. This is not to deny that Quine, and analytic philosophy in his wake, was interested in ontology. Some of the most fundamental philosophical questions that have vexed philosophers in the last fifty years are ontological questions: Are there numbers? Are there properties? Are there events? And if there are any of these kinds of things, what is their nature? But post-Quinean philosophers often set about answering these questions by looking at the language we use when we talk about numbers, properties and events. For example, philosophers engaged in the debate between realists and nominalists about universals would ask whether talk of redness could be adequately paraphrased by talk of red things. If so, the nominalist concluded that we are not committed to the existence of universals. If not, the realist concluded that we cannot escape commitment to them. Heil recommends that we abandon this methodology, for it leads us up blind alleys and conceals more acceptable positions from us. We should instead turn our attention directly onto ontological matters. (shrink)